Case report: Suspected plasmablastic lymphoma in a dog resembling the clinical presentation in humans

Case report: Suspected plasmablastic lymphoma in a dog resembling the clinical presentation in humans

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Plasmablastic lymphoma (PBL) is a rare form of lymphoma in people.PBL originates from plasmablasts and usually presents with swelling/mass in the mouth/neck.A 7-year-old Mongrel dog was presented for a large oral and neck mass.Cytology and histopathology were suggestive of a round cell tumor that was suspected to be lymphoma.An immunohistochemical (IHC) stain panel showed positive Harnesses Pickup for CD18, thus supporting the diagnosis of round cell tumor, but negative for T- and B-cell lymphomas, CD3, CD20, and PAX-5.

Other markers including cytokeratin AE1/3 (for epithelial cell origin), CD31 (for endothelial cells), SOX10 (for melanoma), IBa-1 (for histiocytic Hayward Commercial White Goods sarcoma), and CD117 (for mast cell tumor) were all negative.MUM-1 (for plasma cell differentiation) was strongly positive and CD79a (B cell and plasma cells) was also scantly positive.Based on the histopathology and immunohistochemistry results in combination with the clinical presentation, a suspected diagnosis of PBL was made.As per available literature, this is perhaps the first highly suspected case of PBL in a dog.